Assay Detail
Binding
CHEMBL5527359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Plasmodium falciparum SUB1 using Ac-CKITAQDDEESC-OH as fluorogenic substrate pre-incubated for 5 mins followed by substrate addition and measured every 3 mins for 60 mins by fluorescence based SpectraMax M5e plate reader
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Subtilisin-like protease 1 (CHEMBL2052035) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Peptidic Boronic Acid <i>Plasmodium falciparum</i> SUB1 Inhibitors with Improved Selectivity over Human Proteasome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.10 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5568491 | — | — | 1 | 8.70 |
| CHEMBL5561987 | — | — | 1 | 8.68 |
| CHEMBL5532138 | — | — | 1 | 8.55 |
| CHEMBL5561563 | — | — | 1 | 8.49 |
| CHEMBL5563634 | — | — | 1 | 8.47 |
| CHEMBL5560073 | — | — | 1 | 8.41 |
| CHEMBL5561245 | — | — | 1 | 8.41 |
| CHEMBL5562881 | — | — | 1 | 8.27 |
| CHEMBL5564605 | — | — | 1 | 8.17 |
| CHEMBL5565717 | — | — | 1 | 8.16 |
| CHEMBL5561949 | — | — | 1 | 8.16 |
| CHEMBL5563835 | — | — | 1 | 8.12 |
| CHEMBL5559405 | — | — | 1 | 8.11 |
| CHEMBL5556185 | — | — | 1 | 8.03 |
| CHEMBL5567696 | — | — | 1 | 8.02 |
| CHEMBL5562284 | — | — | 1 | 7.88 |
| CHEMBL5567647 | — | — | 1 | 7.82 |
| CHEMBL5561366 | — | — | 1 | 7.63 |
| CHEMBL5561760 | — | — | 1 | 7.44 |
| CHEMBL5555306 | — | — | 1 | 7.36 |
| CHEMBL5565877 | — | — | 1 | 7.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5568491 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5561987 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5532138 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5561563 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5563634 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5560073 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5561245 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5562881 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL5564605 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5565717 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5561949 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5563835 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5559405 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL5556185 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL5567696 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL5562284 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL5567647 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL5561366 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL5561760 | — | IC50 | = | 36.1 | nM | 7.44 |
| CHEMBL5555306 | — | IC50 | = | 43.5 | nM | 7.36 |
| CHEMBL5565877 | — | IC50 | = | 71.0 | nM | 7.15 |