Compound Detail
CHEMBL5561949
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CC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)B(O)O)C1CCCC1
Basic Information
| ChEMBL ID | CHEMBL5561949 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NWSNXGBUSHMFLC-DCPHZVHLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
460.3
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Subtilisin-like protease 1 CHEMBL2052035 | IC50 | 8.16 | 8.16 | 6.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Subtilisin-like protease 1 | IC50 | = | 6.9 | nM | 8.16 | Inhibition of recombinant Plasmodium falciparum SUB1 using Ac-CKITAQDDEESC-OH as... | 39051854 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39051854 | 10.1021/acs.jmedchem.4c01005 | Subtilisin-like protease 1 | 1 |
Data from ChEMBL 36 via Core Engine