Assay Detail
Functional
CHEMBL5528520
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Agonist activity at human GPR40 stably expressed in CHO cells assessed as increase in intracellular calcium concentration by FLIPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthetic GPR40/FFAR1 agonists: An exhaustive survey on the most recent chemical classes and their structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.19 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207881 | GW9508 | — | 1 | 7.10 |
| CHEMBL5571474 | — | — | 1 | 7.10 |
| CHEMBL5572665 | — | — | 1 | 5.68 |
| CHEMBL1325260 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207881 | GW9508 | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5571474 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5572665 | — | EC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL1325260 | — | EC50 | = | 13160.0 | nM | 4.88 |