Assay Detail
Functional
CHEMBL5528688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MOLM-14 cells harboring FLT3-F691L mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-14 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 7.00 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591269 | — | — | 1 | 8.15 |
| CHEMBL5563397 | — | — | 1 | 8.13 |
| CHEMBL5575586 | — | — | 1 | 8.08 |
| CHEMBL5569019 | — | — | 1 | 8.01 |
| CHEMBL5573225 | — | — | 1 | 8.00 |
| CHEMBL5572898 | — | — | 1 | 7.90 |
| CHEMBL5595005 | — | — | 1 | 7.85 |
| CHEMBL5571822 | — | — | 1 | 7.84 |
| CHEMBL5567007 | — | — | 1 | 7.72 |
| CHEMBL5592538 | — | — | 1 | 7.54 |
| CHEMBL5574627 | — | — | 1 | 7.49 |
| CHEMBL5569292 | — | — | 1 | 7.27 |
| CHEMBL3301622 | GILTERITINIB | 4.0 | 1 | 7.23 |
| CHEMBL5574019 | — | — | 1 | 7.04 |
| CHEMBL5590090 | — | — | 1 | 7.01 |
| CHEMBL5557310 | — | — | 1 | 6.98 |
| CHEMBL5569052 | — | — | 1 | 6.89 |
| CHEMBL5569879 | — | — | 1 | 6.87 |
| CHEMBL5575457 | — | — | 1 | 6.85 |
| CHEMBL5574518 | — | — | 1 | 6.80 |
| CHEMBL5589647 | — | — | 1 | 6.74 |
| CHEMBL5575311 | — | — | 1 | 6.62 |
| CHEMBL5573164 | — | — | 1 | 6.59 |
| CHEMBL5568659 | — | — | 1 | 6.53 |
| CHEMBL5555704 | — | — | 1 | 6.53 |
| CHEMBL5555244 | — | — | 1 | 6.52 |
| CHEMBL5570582 | — | — | 1 | 6.50 |
| CHEMBL5571612 | — | — | 1 | 6.47 |
| CHEMBL5562812 | — | — | 1 | 6.38 |
| CHEMBL5571391 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591269 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL5563397 | — | IC50 | = | 7.42 | nM | 8.13 |
| CHEMBL5575586 | — | IC50 | = | 8.34 | nM | 8.08 |
| CHEMBL5569019 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL5573225 | — | IC50 | = | 9.98 | nM | 8.00 |
| CHEMBL5572898 | — | IC50 | = | 12.47 | nM | 7.90 |
| CHEMBL5595005 | — | IC50 | = | 13.99 | nM | 7.85 |
| CHEMBL5571822 | — | IC50 | = | 14.42 | nM | 7.84 |
| CHEMBL5567007 | — | IC50 | = | 18.95 | nM | 7.72 |
| CHEMBL5592538 | — | IC50 | = | 28.85 | nM | 7.54 |
| CHEMBL5574627 | — | IC50 | = | 32.59 | nM | 7.49 |
| CHEMBL5569292 | — | IC50 | = | 54.16 | nM | 7.27 |
| CHEMBL3301622 | GILTERITINIB | IC50 | = | 58.78 | nM | 7.23 |
| CHEMBL5574019 | — | IC50 | = | 90.7 | nM | 7.04 |
| CHEMBL5590090 | — | IC50 | = | 97.46 | nM | 7.01 |
| CHEMBL5557310 | — | IC50 | = | 105.2 | nM | 6.98 |
| CHEMBL5569052 | — | IC50 | = | 130.1 | nM | 6.89 |
| CHEMBL5569879 | — | IC50 | = | 134.9 | nM | 6.87 |
| CHEMBL5575457 | — | IC50 | = | 142.1 | nM | 6.85 |
| CHEMBL5574518 | — | IC50 | = | 160.1 | nM | 6.80 |
| CHEMBL5589647 | — | IC50 | = | 183.5 | nM | 6.74 |
| CHEMBL5575311 | — | IC50 | = | 238.5 | nM | 6.62 |
| CHEMBL5573164 | — | IC50 | = | 258.8 | nM | 6.59 |
| CHEMBL5555704 | — | IC50 | = | 293.1 | nM | 6.53 |
| CHEMBL5568659 | — | IC50 | = | 294.47 | nM | 6.53 |
| CHEMBL5555244 | — | IC50 | = | 304.1 | nM | 6.52 |
| CHEMBL5570582 | — | IC50 | = | 314.5 | nM | 6.50 |
| CHEMBL5571612 | — | IC50 | = | 336.8 | nM | 6.47 |
| CHEMBL5562812 | — | IC50 | = | 412.4 | nM | 6.38 |
| CHEMBL5571391 | — | IC50 | = | 425.7 | nM | 6.37 |
| CHEMBL5573079 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL5571723 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL5566854 | — | IC50 | = | 566.3 | nM | 6.25 |
| CHEMBL5566186 | — | IC50 | = | 792.3 | nM | 6.10 |
| CHEMBL5556978 | — | IC50 | = | 794.4 | nM | 6.10 |
| CHEMBL5573680 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5566645 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5569381 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL24828 | VANDETANIB | IC50 | > | 20000.0 | nM | - |
| CHEMBL5565983 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5592651 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5542394 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5575709 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5556060 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5566699 | — | IC50 | > | 1000.0 | nM | - |