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Assay Detail

CHEMBL5528713

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human Eca-109 cells assessed as inhibition of cell growth incubated for 24 hrs under dark condition of 0 J/cm^2 by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type ECa-109
Confidence 1 — Organism
Curated By Autocuration

Target

ECa-109 cell line (CHEMBL614668)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and evaluation of novel meso-substitutedphenyl dithieno[3,2-b]thiophene-fused BODIPY derivatives as efficient photosensitizers for photodynamic therapy.
Cao N, Jiang Y, Song ZB, Chen D, Wu D, Chen ZL, Yan YJ.
Eur J Med Chem (2024) 264 : 116012 -116012
PubMed 38056302 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.60 5.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5571435 1 5.90
CHEMBL5570231 1 5.88
CHEMBL500576 TEMOPORFIN 4.0 1 5.85
CHEMBL5593921 1 5.84
CHEMBL5566030 1 5.82
CHEMBL5555912 1 5.78
CHEMBL5590207 1 5.75
CHEMBL5590479 1 5.70
CHEMBL5573837 1 5.67
CHEMBL5565444 1 5.66
CHEMBL5543036 1 5.62
CHEMBL5592001 1 5.60
CHEMBL5565483 1 5.49
CHEMBL5556480 1 5.31
CHEMBL5566693 1 5.28
CHEMBL5570495 1 5.28
CHEMBL5566872 1 5.24
CHEMBL5593204 1 5.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5571435 IC50 = 1260.0 nM 5.90
CHEMBL5570231 IC50 = 1330.0 nM 5.88
CHEMBL500576 TEMOPORFIN IC50 = 1420.0 nM 5.85
CHEMBL5593921 IC50 = 1430.0 nM 5.84
CHEMBL5566030 IC50 = 1530.0 nM 5.82
CHEMBL5555912 IC50 = 1680.0 nM 5.78
CHEMBL5590207 IC50 = 1790.0 nM 5.75
CHEMBL5590479 IC50 = 2000.0 nM 5.70
CHEMBL5573837 IC50 = 2120.0 nM 5.67
CHEMBL5565444 IC50 = 2200.0 nM 5.66
CHEMBL5543036 IC50 = 2410.0 nM 5.62
CHEMBL5592001 IC50 = 2500.0 nM 5.60
CHEMBL5565483 IC50 = 3270.0 nM 5.49
CHEMBL5556480 IC50 = 4920.0 nM 5.31
CHEMBL5566693 IC50 = 5310.0 nM 5.28
CHEMBL5570495 IC50 = 5230.0 nM 5.28
CHEMBL5566872 IC50 = 5780.0 nM 5.24
CHEMBL5593204 IC50 = 7520.0 nM 5.12