Assay Detail
Binding
CHEMBL5529083
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Inhibition of human erythrocyte AChE incubated for 10 mins
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of carbamate derivatives incorporating multifunctional carrier scaffolds as pseudo-irreversible cholinesterase inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.86 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570989 | — | — | 1 | 8.08 |
| CHEMBL5575345 | — | — | 1 | 7.67 |
| CHEMBL5572008 | — | — | 1 | 7.64 |
| CHEMBL5595199 | — | — | 1 | 7.59 |
| CHEMBL5562554 | — | — | 1 | 7.52 |
| CHEMBL5592335 | — | — | 1 | 7.42 |
| CHEMBL5573861 | — | — | 1 | 7.38 |
| CHEMBL5572861 | — | — | 1 | 7.32 |
| CHEMBL5563794 | — | — | 1 | 7.26 |
| CHEMBL5569081 | — | — | 1 | 7.25 |
| CHEMBL5594238 | — | — | 1 | 7.23 |
| CHEMBL5566825 | — | — | 1 | 7.19 |
| CHEMBL5594287 | — | — | 1 | 6.95 |
| CHEMBL5567590 | — | — | 1 | 6.93 |
| CHEMBL5575737 | — | — | 1 | 6.93 |
| CHEMBL5564010 | — | — | 1 | 6.82 |
| CHEMBL5567396 | — | — | 1 | 6.82 |
| CHEMBL5563760 | — | — | 1 | 6.82 |
| CHEMBL5583890 | — | — | 1 | 6.69 |
| CHEMBL5573148 | — | — | 1 | 6.63 |
| CHEMBL5568634 | — | — | 1 | 6.61 |
| CHEMBL5567533 | — | — | 1 | 6.60 |
| CHEMBL5583827 | — | — | 1 | 6.56 |
| CHEMBL5575441 | — | — | 1 | 6.53 |
| CHEMBL5575695 | — | — | 1 | 6.53 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.51 |
| CHEMBL5569423 | — | — | 1 | 6.50 |
| CHEMBL5568668 | — | — | 1 | 6.42 |
| CHEMBL5571160 | — | — | 1 | 6.41 |
| CHEMBL5574879 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570989 | — | IC50 | = | 8.28 | nM | 8.08 |
| CHEMBL5575345 | — | IC50 | = | 21.34 | nM | 7.67 |
| CHEMBL5572008 | — | IC50 | = | 23.11 | nM | 7.64 |
| CHEMBL5595199 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL5562554 | — | IC50 | = | 30.35 | nM | 7.52 |
| CHEMBL5592335 | — | IC50 | = | 37.83 | nM | 7.42 |
| CHEMBL5573861 | — | IC50 | = | 42.16 | nM | 7.38 |
| CHEMBL5572861 | — | IC50 | = | 47.67 | nM | 7.32 |
| CHEMBL5563794 | — | IC50 | = | 55.03 | nM | 7.26 |
| CHEMBL5569081 | — | IC50 | = | 55.99 | nM | 7.25 |
| CHEMBL5594238 | — | IC50 | = | 59.14 | nM | 7.23 |
| CHEMBL5566825 | — | IC50 | = | 64.71 | nM | 7.19 |
| CHEMBL5594287 | — | IC50 | = | 113.11 | nM | 6.95 |
| CHEMBL5567590 | — | IC50 | = | 117.15 | nM | 6.93 |
| CHEMBL5575737 | — | IC50 | = | 118.56 | nM | 6.93 |
| CHEMBL5567396 | — | IC50 | = | 151.7 | nM | 6.82 |
| CHEMBL5564010 | — | IC50 | = | 152.6 | nM | 6.82 |
| CHEMBL5563760 | — | IC50 | = | 152.72 | nM | 6.82 |
| CHEMBL5583890 | — | IC50 | = | 204.8 | nM | 6.69 |
| CHEMBL5573148 | — | IC50 | = | 232.7 | nM | 6.63 |
| CHEMBL5568634 | — | IC50 | = | 247.73 | nM | 6.61 |
| CHEMBL5567533 | — | IC50 | = | 252.47 | nM | 6.60 |
| CHEMBL5583827 | — | IC50 | = | 273.1 | nM | 6.56 |
| CHEMBL5575441 | — | IC50 | = | 297.19 | nM | 6.53 |
| CHEMBL5575695 | — | IC50 | = | 292.22 | nM | 6.53 |
| CHEMBL95 | TACRINE | IC50 | = | 305.87 | nM | 6.51 |
| CHEMBL5569423 | — | IC50 | = | 317.48 | nM | 6.50 |
| CHEMBL5568668 | — | IC50 | = | 381.73 | nM | 6.42 |
| CHEMBL5571160 | — | IC50 | = | 385.33 | nM | 6.41 |
| CHEMBL5574879 | — | IC50 | = | 421.09 | nM | 6.38 |
| CHEMBL5575440 | — | IC50 | = | 510.16 | nM | 6.29 |
| CHEMBL5564643 | — | IC50 | = | 551.69 | nM | 6.26 |
| CHEMBL5556622 | — | IC50 | = | 1253.62 | nM | 5.90 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 2290.97 | nM | 5.64 |
| CHEMBL5572620 | — | IC50 | > | 10000.0 | nM | - |