Assay Detail
Binding
CHEMBL5529084
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate incubated for 10 mins followed by substrate addition and measured after 10 mins by DTNB reagent based Ellman's method
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of carbamate derivatives incorporating multifunctional carrier scaffolds as pseudo-irreversible cholinesterase inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.40 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5556622 | — | — | 1 | 9.43 |
| CHEMBL5575440 | — | — | 1 | 8.87 |
| CHEMBL5564643 | — | — | 1 | 8.14 |
| CHEMBL5569081 | — | — | 1 | 8.02 |
| CHEMBL5573861 | — | — | 1 | 7.96 |
| CHEMBL5567590 | — | — | 1 | 7.92 |
| CHEMBL5575737 | — | — | 1 | 7.83 |
| CHEMBL5573148 | — | — | 1 | 7.79 |
| CHEMBL5575345 | — | — | 1 | 7.74 |
| CHEMBL5583890 | — | — | 1 | 7.69 |
| CHEMBL5564010 | — | — | 1 | 7.67 |
| CHEMBL5572861 | — | — | 1 | 7.67 |
| CHEMBL5571160 | — | — | 1 | 7.63 |
| CHEMBL5574879 | — | — | 1 | 7.63 |
| CHEMBL5570989 | — | — | 1 | 7.57 |
| CHEMBL5583827 | — | — | 1 | 7.40 |
| CHEMBL5575441 | — | — | 1 | 7.37 |
| CHEMBL5569423 | — | — | 1 | 7.37 |
| CHEMBL5575695 | — | — | 1 | 7.36 |
| CHEMBL5562554 | — | — | 1 | 7.32 |
| CHEMBL5568634 | — | — | 1 | 7.31 |
| CHEMBL5572620 | — | — | 1 | 7.28 |
| CHEMBL5594287 | — | — | 1 | 7.24 |
| CHEMBL5563760 | — | — | 1 | 7.19 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.14 |
| CHEMBL5568668 | — | — | 1 | 7.12 |
| CHEMBL5595199 | — | — | 1 | 7.03 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 6.98 |
| CHEMBL5592335 | — | — | 1 | 6.86 |
| CHEMBL5566825 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5556622 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL5575440 | — | IC50 | = | 1.35 | nM | 8.87 |
| CHEMBL5564643 | — | IC50 | = | 7.23 | nM | 8.14 |
| CHEMBL5569081 | — | IC50 | = | 9.65 | nM | 8.02 |
| CHEMBL5573861 | — | IC50 | = | 10.97 | nM | 7.96 |
| CHEMBL5567590 | — | IC50 | = | 11.99 | nM | 7.92 |
| CHEMBL5575737 | — | IC50 | = | 14.81 | nM | 7.83 |
| CHEMBL5573148 | — | IC50 | = | 16.12 | nM | 7.79 |
| CHEMBL5575345 | — | IC50 | = | 18.32 | nM | 7.74 |
| CHEMBL5583890 | — | IC50 | = | 20.46 | nM | 7.69 |
| CHEMBL5564010 | — | IC50 | = | 21.23 | nM | 7.67 |
| CHEMBL5572861 | — | IC50 | = | 21.64 | nM | 7.67 |
| CHEMBL5571160 | — | IC50 | = | 23.22 | nM | 7.63 |
| CHEMBL5574879 | — | IC50 | = | 23.34 | nM | 7.63 |
| CHEMBL5570989 | — | IC50 | = | 26.86 | nM | 7.57 |
| CHEMBL5583827 | — | IC50 | = | 40.02 | nM | 7.40 |
| CHEMBL5569423 | — | IC50 | = | 43.13 | nM | 7.37 |
| CHEMBL5575441 | — | IC50 | = | 43.11 | nM | 7.37 |
| CHEMBL5575695 | — | IC50 | = | 43.45 | nM | 7.36 |
| CHEMBL5562554 | — | IC50 | = | 48.03 | nM | 7.32 |
| CHEMBL5568634 | — | IC50 | = | 48.58 | nM | 7.31 |
| CHEMBL5572620 | — | IC50 | = | 52.22 | nM | 7.28 |
| CHEMBL5594287 | — | IC50 | = | 57.9 | nM | 7.24 |
| CHEMBL5563760 | — | IC50 | = | 64.4 | nM | 7.19 |
| CHEMBL95 | TACRINE | IC50 | = | 72.71 | nM | 7.14 |
| CHEMBL5568668 | — | IC50 | = | 76.53 | nM | 7.12 |
| CHEMBL5595199 | — | IC50 | = | 92.82 | nM | 7.03 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 105.3 | nM | 6.98 |
| CHEMBL5592335 | — | IC50 | = | 136.87 | nM | 6.86 |
| CHEMBL5566825 | — | IC50 | = | 279.65 | nM | 6.55 |
| CHEMBL5567396 | — | IC50 | = | 333.98 | nM | 6.48 |
| CHEMBL5563794 | — | IC50 | = | 555.81 | nM | 6.25 |
| CHEMBL5594238 | — | IC50 | = | 791.11 | nM | 6.10 |
| CHEMBL5572008 | — | IC50 | = | 1655.8 | nM | 5.78 |
| CHEMBL5567533 | — | IC50 | > | 10000.0 | nM | - |