Assay Detail
Binding
CHEMBL5529148
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Inhibition of Escherichia coli FabH
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Beta-ketoacyl-[acyl-carrier-protein] synthase III (CHEMBL4914) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Target identification, and optimization of dioxygenated amide derivatives as potent antibacterial agents with FabH inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.86 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555396 | — | — | 1 | 5.70 |
| CHEMBL5573853 | — | — | 1 | 5.31 |
| CHEMBL5564510 | — | — | 1 | 5.07 |
| CHEMBL5570580 | — | — | 1 | 4.88 |
| CHEMBL5575822 | — | — | 1 | 4.76 |
| CHEMBL5571510 | — | — | 1 | 4.71 |
| CHEMBL5569660 | — | — | 1 | 4.57 |
| CHEMBL5564498 | — | — | 1 | 4.42 |
| CHEMBL5550063 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555396 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5573853 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5564510 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL5570580 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL5575822 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL5571510 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL5569660 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL5564498 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL5550063 | — | IC50 | = | 46400.0 | nM | 4.33 |