Assay Detail
Binding
CHEMBL5529675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ATM in human HT-29 cells incubated for 2 hrs by Alexa Fluor 488/Hoeschst staining based plate reader assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.36 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5573231 | — | — | 1 | 9.90 |
| CHEMBL5572255 | — | — | 1 | 9.60 |
| CHEMBL5567522 | — | — | 1 | 9.60 |
| CHEMBL5171429 | — | — | 1 | 9.60 |
| CHEMBL5182423 | — | — | 1 | 9.40 |
| CHEMBL5571791 | — | — | 1 | 9.30 |
| CHEMBL5573212 | — | — | 1 | 9.30 |
| CHEMBL3960662 | — | — | 1 | 9.20 |
| CHEMBL5595653 | — | — | 1 | 9.10 |
| CHEMBL4594429 | AZD-1390 | 1.0 | 1 | 9.10 |
| CHEMBL5565468 | — | — | 1 | 9.00 |
| CHEMBL5555756 | — | — | 1 | 9.00 |
| CHEMBL5566946 | — | — | 1 | 8.80 |
| CHEMBL5583538 | — | — | 1 | 8.70 |
| CHEMBL5575507 | — | — | 1 | 8.70 |
| CHEMBL5567347 | — | — | 1 | 8.50 |
| CHEMBL5569887 | — | — | 1 | 8.20 |
| CHEMBL5575600 | — | — | 1 | 8.20 |
| CHEMBL5571248 | — | — | 1 | 8.00 |
| CHEMBL5571179 | — | — | 1 | 7.90 |
| CHEMBL5570730 | — | — | 1 | 7.90 |
| CHEMBL5566892 | — | — | 1 | 7.90 |
| CHEMBL5569852 | — | — | 1 | 7.90 |
| CHEMBL5590607 | — | — | 1 | 7.40 |
| CHEMBL5563436 | — | — | 1 | 7.40 |
| CHEMBL5567014 | — | — | 1 | 7.40 |
| CHEMBL5573686 | — | — | 1 | 7.40 |
| CHEMBL5532085 | — | — | 1 | 7.30 |
| CHEMBL5178407 | — | — | 1 | 6.51 |
| CHEMBL4169828 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5573231 | — | IC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL5572255 | — | IC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL5567522 | — | IC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL5171429 | — | IC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL5182423 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL5571791 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL5573212 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL3960662 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL5595653 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL4594429 | AZD-1390 | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL5565468 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5555756 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5566946 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL5583538 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL5575507 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL5567347 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL5569887 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL5575600 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL5571248 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5571179 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL5570730 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL5566892 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL5569852 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL5590607 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5563436 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5567014 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5573686 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5532085 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5178407 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4169828 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4167508 | — | IC50 | = | 398.11 | nM | 6.40 |