Assay Detail
Binding
CHEMBL5529786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p300/CBP (unknown origin) using histone H3 (1 to 21 residues) as substrate incubated for 90 mins by AlphaLISA assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
CREB-binding protein/Histone acetyltransferase p300 (CHEMBL3883300) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.56 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5567101 | — | — | 1 | 7.60 |
| CHEMBL5564786 | — | — | 1 | 7.58 |
| CHEMBL4785363 | INOBRODIB | 1.0 | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5567101 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5564786 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4785363 | INOBRODIB | IC50 | = | 32.0 | nM | 7.50 |