Assay Detail
Binding
CHEMBL5529915
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Binding affinity to BTK (unknown origin) assessed as inhibition constant measured after 60 mins incubation by microtiter-plate reader
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Potent and Fast BTK PROTACs for the Treatment of Osteoclasts-Related Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.91 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 9.62 |
| CHEMBL5583871 | — | — | 1 | 7.30 |
| CHEMBL5583805 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL5583871 | — | Ki | = | 50.28 | nM | 7.30 |
| CHEMBL5583805 | — | Ki | = | 151.93 | nM | 6.82 |