Assay Detail
Functional
CHEMBL5530504
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550L mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.03 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3908979 | FGF401 | 2.0 | 1 | 8.77 |
| CHEMBL5574272 | — | — | 1 | 7.87 |
| CHEMBL3939295 | H3B-6527 | 1.0 | 1 | 7.45 |
| CHEMBL4514636 | FISOGATINIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3908979 | FGF401 | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5574272 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL3939295 | H3B-6527 | IC50 | = | 35.5 | nM | 7.45 |
| CHEMBL4514636 | FISOGATINIB | IC50 | > | 2000.0 | nM | - |