Assay Detail
Binding
CHEMBL5531239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to androgen receptor LBD (unknown origin) incubated for 2 hrs by fluorescence polarization assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Dual-Target Inhibitors Targeting Androgen Receptors and Glucocorticoid Receptors to Overcome Antiandrogen Resistance in Castration-Resistant Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.40 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3183409 | APALUTAMIDE | 4.0 | 1 | 6.46 |
| CHEMBL5550018 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3183409 | APALUTAMIDE | IC50 | = | 348.9 | nM | 6.46 |
| CHEMBL5550018 | — | IC50 | = | 458.0 | nM | 6.34 |