Assay Detail
Binding
CHEMBL5531335
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Activation of PKM2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mechanistic Investigation of Thiazole-Based Pyruvate Kinase M2 Inhibitor Causing Tumor Regression in Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.56 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL449579 | MICHELIOLIDE | — | 1 | 8.22 |
| CHEMBL4299940 | MITAPIVAT | 4.0 | 1 | 7.70 |
| CHEMBL1089334 | — | — | 1 | 7.52 |
| CHEMBL5274026 | — | — | 1 | 7.30 |
| CHEMBL1085588 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL449579 | MICHELIOLIDE | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4299940 | MITAPIVAT | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1089334 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5274026 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1085588 | — | EC50 | = | 90.0 | nM | 7.05 |