Assay Detail
Binding
CHEMBL5533353
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal FLAG-tagged mTORC2 (unknown origin) expressed in HeLa cells incubated for 20 mins in presence of ATP by SDS-PAGE based immunoblotting analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
MNK, mTOR or eIF4E-selecting the best anti-tumor target for blocking translation initiation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1256459 | TORIN1 | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1256459 | TORIN1 | IC50 | = | 2.0 | nM | 8.70 |