Assay Detail
Binding
CHEMBL5533431
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JNK3 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using ATF2 as substrate in presence of ATP by HTRF assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting protein kinases for the treatment of Alzheimer's disease: Recent progress and future perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.26 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1233747 | — | — | 1 | 7.60 |
| CHEMBL5569575 | — | — | 1 | 7.13 |
| CHEMBL3355178 | — | — | 1 | 6.68 |
| CHEMBL3355181 | — | — | 1 | 6.51 |
| CHEMBL4753641 | — | — | 1 | 5.87 |
| CHEMBL4778645 | — | — | 1 | 5.70 |
| CHEMBL4784092 | — | — | 1 | 5.57 |
| CHEMBL5572325 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1233747 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5569575 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3355178 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3355181 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL4753641 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4778645 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4784092 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5572325 | — | IC50 | = | 9270.0 | nM | 5.03 |