Assay Detail
Functional
CHEMBL5533522
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Anti-ferroptotic activity in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
35
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-hydroxyl pyrazole derivatives as potent ferroptosis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 35 | 7.31 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571170 | — | — | 1 | 8.07 |
| CHEMBL5571303 | — | — | 2 | 7.72 |
| CHEMBL5568615 | — | — | 1 | 7.66 |
| CHEMBL5593522 | — | — | 1 | 7.65 |
| CHEMBL5563517 | — | — | 1 | 7.64 |
| CHEMBL3633556 | — | — | 1 | 7.63 |
| CHEMBL5564505 | — | — | 2 | 7.61 |
| CHEMBL5573105 | — | — | 1 | 7.61 |
| CHEMBL5583546 | — | — | 1 | 7.59 |
| CHEMBL5574049 | — | — | 1 | 7.58 |
| CHEMBL5564001 | — | — | 1 | 7.56 |
| CHEMBL5570171 | — | — | 1 | 7.50 |
| CHEMBL5570957 | — | — | 1 | 7.40 |
| CHEMBL5570102 | — | — | 2 | 7.37 |
| CHEMBL5575040 | — | — | 1 | 7.35 |
| CHEMBL5571661 | — | — | 1 | 7.35 |
| CHEMBL5563357 | — | — | 1 | 7.29 |
| CHEMBL5567399 | — | — | 1 | 7.28 |
| CHEMBL5569892 | — | — | 1 | 7.25 |
| CHEMBL5572025 | — | — | 1 | 7.16 |
| CHEMBL5571417 | — | — | 1 | 7.10 |
| CHEMBL5572227 | — | — | 1 | 7.10 |
| CHEMBL5574558 | — | — | 1 | 7.09 |
| CHEMBL5575591 | — | — | 1 | 7.02 |
| CHEMBL5573845 | — | — | 1 | 6.92 |
| CHEMBL5572658 | — | — | 1 | 6.82 |
| CHEMBL6067707 | — | — | 1 | 6.73 |
| CHEMBL5590943 | — | — | 1 | 6.73 |
| CHEMBL5570248 | — | — | 1 | 6.14 |
| CHEMBL218059 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571170 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL5571303 | — | EC50 | = | 18.9 | nM | 7.72 |
| CHEMBL5568615 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5593522 | — | EC50 | = | 22.6 | nM | 7.65 |
| CHEMBL5563517 | — | EC50 | = | 23.1 | nM | 7.64 |
| CHEMBL3633556 | — | EC50 | = | 23.4 | nM | 7.63 |
| CHEMBL5564505 | — | EC50 | = | 24.8 | nM | 7.61 |
| CHEMBL5573105 | — | EC50 | = | 24.6 | nM | 7.61 |
| CHEMBL5583546 | — | EC50 | = | 25.9 | nM | 7.59 |
| CHEMBL5574049 | — | EC50 | = | 26.1 | nM | 7.58 |
| CHEMBL5564001 | — | EC50 | = | 27.4 | nM | 7.56 |
| CHEMBL5571303 | — | EC50 | = | 30.8 | nM | 7.51 |
| CHEMBL5570171 | — | EC50 | = | 31.7 | nM | 7.50 |
| CHEMBL5564505 | — | EC50 | = | 32.1 | nM | 7.49 |
| CHEMBL5570957 | — | EC50 | = | 39.5 | nM | 7.40 |
| CHEMBL5570102 | — | EC50 | = | 42.4 | nM | 7.37 |
| CHEMBL5575040 | — | EC50 | = | 44.8 | nM | 7.35 |
| CHEMBL5571661 | — | EC50 | = | 44.8 | nM | 7.35 |
| CHEMBL5563357 | — | EC50 | = | 51.1 | nM | 7.29 |
| CHEMBL5567399 | — | EC50 | = | 52.7 | nM | 7.28 |
| CHEMBL5569892 | — | EC50 | = | 56.6 | nM | 7.25 |
| CHEMBL5572025 | — | EC50 | = | 69.1 | nM | 7.16 |
| CHEMBL5571417 | — | EC50 | = | 80.2 | nM | 7.10 |
| CHEMBL5572227 | — | EC50 | = | 79.6 | nM | 7.10 |
| CHEMBL5570102 | — | EC50 | = | 79.6 | nM | 7.10 |
| CHEMBL5574558 | — | EC50 | = | 81.9 | nM | 7.09 |
| CHEMBL5575591 | — | EC50 | = | 94.9 | nM | 7.02 |
| CHEMBL5573845 | — | EC50 | = | 120.1 | nM | 6.92 |
| CHEMBL5572658 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5590943 | — | EC50 | = | 187.2 | nM | 6.73 |
| CHEMBL6067707 | — | EC50 | = | 187.2 | nM | 6.73 |
| CHEMBL5570248 | — | EC50 | = | 720.5 | nM | 6.14 |
| CHEMBL218059 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5569369 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5570635 | — | EC50 | > | 1000.0 | nM | - |