Assay Detail
Functional
CHEMBL5533523
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Anti-ferroptotic activity against imidazole ketone erastin (IKE) induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-hydroxyl pyrazole derivatives as potent ferroptosis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.22 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571170 | — | — | 1 | 7.32 |
| CHEMBL3633556 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571170 | — | EC50 | = | 48.3 | nM | 7.32 |
| CHEMBL3633556 | — | EC50 | = | 75.2 | nM | 7.12 |