Assay Detail
Binding
CHEMBL5533636
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MAGL using 4-nitrophenylacetate as substrate incubated for 30 mins by microplate reader analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.72 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5567027 | — | — | 1 | 8.89 |
| CHEMBL5176915 | — | — | 1 | 8.68 |
| CHEMBL5595401 | — | — | 1 | 8.60 |
| CHEMBL5567389 | — | — | 1 | 8.57 |
| CHEMBL5570158 | — | — | 1 | 8.28 |
| CHEMBL5590627 | — | — | 1 | 8.15 |
| CHEMBL5571621 | — | — | 1 | 7.88 |
| CHEMBL5574704 | — | — | 1 | 7.84 |
| CHEMBL5549926 | — | — | 1 | 7.68 |
| CHEMBL5573282 | — | — | 1 | 7.65 |
| CHEMBL5575182 | — | — | 1 | 7.49 |
| CHEMBL5549920 | — | — | 1 | 7.39 |
| CHEMBL5563136 | — | — | 1 | 7.35 |
| CHEMBL576786 | — | — | 1 | 7.33 |
| CHEMBL5593092 | — | — | 1 | 7.31 |
| CHEMBL5570616 | — | — | 1 | 7.21 |
| CHEMBL5565395 | — | — | 1 | 6.95 |
| CHEMBL5574429 | — | — | 1 | 6.83 |
| CHEMBL5564512 | — | — | 1 | 6.62 |
| CHEMBL5570539 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5567027 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5176915 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5595401 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5567389 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5570158 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL5590627 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL5571621 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL5574704 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL5549926 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL5573282 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL5575182 | — | IC50 | = | 32.3 | nM | 7.49 |
| CHEMBL5549920 | — | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL5563136 | — | IC50 | = | 44.8 | nM | 7.35 |
| CHEMBL576786 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5593092 | — | IC50 | = | 49.1 | nM | 7.31 |
| CHEMBL5570616 | — | IC50 | = | 61.2 | nM | 7.21 |
| CHEMBL5565395 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL5574429 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL5564512 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL5570539 | — | IC50 | > | 1000.0 | nM | - |