Assay Detail
Binding
CHEMBL5534342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to PIKfyve (unknown origin) assessed as dissociation constant incubated for 1 hr by qPCR analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
1-phosphatidylinositol 3-phosphate 5-kinase (CHEMBL1938222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent and Selective Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitors as Methuosis Inducers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.37 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5572490 | — | — | 1 | 9.33 |
| CHEMBL5568998 | — | — | 1 | 8.78 |
| CHEMBL2032358 | — | — | 1 | 8.43 |
| CHEMBL4126314 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5572490 | — | Kd | = | 0.47 | nM | 9.33 |
| CHEMBL5568998 | — | Kd | = | 1.65 | nM | 8.78 |
| CHEMBL2032358 | — | Kd | = | 3.75 | nM | 8.43 |
| CHEMBL4126314 | — | Kd | = | 115.0 | nM | 6.94 |