Assay Detail
Functional
CHEMBL5534409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of colony formation in human HCT-116 cells preincubated with compound for 1 hr followed by exposure to 2 Gy gamma irradiation and measured after 7 days by crystal violet staining based chemiluminescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.49 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5579700 | — | — | 1 | 8.43 |
| CHEMBL5566630 | — | — | 1 | 7.82 |
| CHEMBL5563712 | — | — | 1 | 7.56 |
| CHEMBL5563688 | — | — | 1 | 7.48 |
| CHEMBL4439259 | AZD-7648 | 1.0 | 1 | 7.42 |
| CHEMBL5569108 | — | — | 1 | 7.32 |
| CHEMBL5571078 | — | — | 1 | 7.17 |
| CHEMBL5571138 | — | — | 1 | 7.10 |
| CHEMBL5579677 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5579700 | — | IC50 | = | 3.76 | nM | 8.43 |
| CHEMBL5566630 | — | IC50 | = | 15.15 | nM | 7.82 |
| CHEMBL5563712 | — | IC50 | = | 27.46 | nM | 7.56 |
| CHEMBL5563688 | — | IC50 | = | 33.26 | nM | 7.48 |
| CHEMBL4439259 | AZD-7648 | IC50 | = | 38.08 | nM | 7.42 |
| CHEMBL5569108 | — | IC50 | = | 47.95 | nM | 7.32 |
| CHEMBL5571078 | — | IC50 | = | 67.98 | nM | 7.17 |
| CHEMBL5571138 | — | IC50 | = | 79.34 | nM | 7.10 |
| CHEMBL5579677 | — | IC50 | = | 83.27 | nM | 7.08 |