Assay Detail
Binding
CHEMBL5534752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wee1 (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.08 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 7.14 |
| CHEMBL214253 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49120 | PD-0166285 | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL214253 | — | IC50 | = | 97.0 | nM | 7.01 |