Assay Detail
Binding
CHEMBL5535654
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Binding affinity to HCV IRES subdomain IIa RNA assessed as reduction in FRET signal by FRET assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Internal ribosome entry site (IRES) (CHEMBL612412) ↗| Type | NUCLEIC-ACID |
| Organism | Hepacivirus hominis |
Publication
Structure-based virtual screening of unbiased and RNA-focused libraries to identify new ligands for the HCV IRES model system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.42 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223608 | — | — | 1 | 5.31 |
| CHEMBL5564851 | — | — | 1 | 4.21 |
| CHEMBL427101 | — | — | 1 | 4.11 |
| CHEMBL5570170 | — | — | 1 | 4.06 |
| CHEMBL5575339 | — | — | 1 | - |
| CHEMBL581893 | — | — | 1 | - |
| CHEMBL5592337 | — | — | 1 | - |
| CHEMBL5563196 | — | — | 1 | - |
| CHEMBL5583536 | — | — | 1 | - |
| CHEMBL5571553 | — | — | 1 | - |
| CHEMBL5575784 | — | — | 1 | - |
| CHEMBL945 | AMILORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223608 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5564851 | — | EC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL427101 | — | EC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL5570170 | — | EC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL5575339 | — | EC50 | = | 413000.0 | nM | - |
| CHEMBL581893 | — | EC50 | = | 120000.0 | nM | - |
| CHEMBL5592337 | — | EC50 | = | 217000.0 | nM | - |
| CHEMBL5563196 | — | EC50 | >= | 500000.0 | nM | - |
| CHEMBL5583536 | — | EC50 | >= | 500000.0 | nM | - |
| CHEMBL5571553 | — | EC50 | >= | 300000.0 | nM | - |
| CHEMBL5575784 | — | EC50 | >= | 1000000.0 | nM | - |
| CHEMBL945 | AMILORIDE | EC50 | >= | 500000.0 | nM | - |