Assay Detail
Binding
CHEMBL5535655
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Binding affinity to HCV IRES subdomain IIa RNA assessed as dissociation constant by MST assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Internal ribosome entry site (IRES) (CHEMBL612412) ↗| Type | NUCLEIC-ACID |
| Organism | Hepacivirus hominis |
Publication
Structure-based virtual screening of unbiased and RNA-focused libraries to identify new ligands for the HCV IRES model system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 4.82 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223608 | — | — | 1 | 5.28 |
| CHEMBL5592337 | — | — | 1 | 5.11 |
| CHEMBL581893 | — | — | 1 | 4.06 |
| CHEMBL5570170 | — | — | 1 | - |
| CHEMBL5564851 | — | — | 1 | - |
| CHEMBL5583536 | — | — | 1 | - |
| CHEMBL5571553 | — | — | 1 | - |
| CHEMBL5575784 | — | — | 1 | - |
| CHEMBL945 | AMILORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223608 | — | Kd | = | 5200.0 | nM | 5.28 |
| CHEMBL5592337 | — | Kd | = | 7800.0 | nM | 5.11 |
| CHEMBL581893 | — | Kd | = | 88000.0 | nM | 4.06 |
| CHEMBL5570170 | — | Kd | >= | 440000.0 | nM | - |
| CHEMBL5564851 | — | Kd | = | 189000.0 | nM | - |
| CHEMBL5583536 | — | Kd | = | 134000.0 | nM | - |
| CHEMBL5571553 | — | Kd | >= | 50000.0 | nM | - |
| CHEMBL5575784 | — | Kd | >= | 100000.0 | nM | - |
| CHEMBL945 | AMILORIDE | Kd | >= | 100000.0 | nM | - |