Assay Detail
Binding
CHEMBL5536359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cathepsin S (unknown origin)
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural Modifications of Covalent Cathepsin S Inhibitors: Impact on Affinity, Selectivity, and Permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 7.89 | 7.89 |
| IC50 | 1 | 10.00 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297638 | PETESICATIB | 2.0 | 1 | 10.00 |
| CHEMBL91704 | K-777 | 2.0 | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297638 | PETESICATIB | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL91704 | K-777 | Ki | = | 13.0 | nM | 7.89 |