Assay Detail
Binding
CHEMBL5536361
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Inhibition of recombinant Cathepsin S (unknown origin) expressed in Escherichia coli using Z-Val-Val-Arg-AMC as substrate by fluorescence based assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural Modifications of Covalent Cathepsin S Inhibitors: Impact on Affinity, Selectivity, and Permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.91 | 10.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5573840 | — | — | 1 | 10.41 |
| CHEMBL5567047 | — | — | 1 | 9.30 |
| CHEMBL249915 | — | — | 1 | 9.00 |
| CHEMBL347111 | — | — | 1 | 8.92 |
| CHEMBL2207560 | — | — | 1 | 8.82 |
| CHEMBL5575199 | — | — | 1 | 8.66 |
| CHEMBL5566228 | — | — | 1 | 8.62 |
| CHEMBL5593543 | — | — | 1 | 8.52 |
| CHEMBL5591918 | — | — | 1 | 8.44 |
| CHEMBL153239 | — | — | 1 | 8.24 |
| CHEMBL5573367 | — | — | 1 | 8.11 |
| CHEMBL5571616 | — | — | 1 | 7.96 |
| CHEMBL356155 | — | — | 1 | 7.96 |
| CHEMBL5574900 | — | — | 1 | 7.89 |
| CHEMBL5572314 | — | — | 1 | 7.89 |
| CHEMBL5549958 | — | — | 1 | 7.89 |
| CHEMBL5574337 | — | — | 1 | 7.70 |
| CHEMBL5572340 | — | — | 1 | 7.60 |
| CHEMBL5567080 | — | — | 1 | 7.21 |
| CHEMBL5589673 | — | — | 1 | 7.17 |
| CHEMBL5595801 | — | — | 1 | 6.93 |
| CHEMBL5592727 | — | — | 1 | 6.84 |
| CHEMBL5594049 | — | — | 1 | 6.78 |
| CHEMBL5570914 | — | — | 1 | 6.48 |
| CHEMBL5564109 | — | — | 1 | 6.42 |
| CHEMBL5590540 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5573840 | — | Ki | = | 0.039 | nM | 10.41 |
| CHEMBL5567047 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL249915 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL347111 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2207560 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL5575199 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL5566228 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL5593543 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5591918 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL153239 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL5573367 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL5571616 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL356155 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5574900 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL5572314 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL5549958 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL5574337 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL5572340 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL5567080 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL5589673 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL5595801 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL5592727 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL5594049 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL5570914 | — | Ki | = | 331.0 | nM | 6.48 |
| CHEMBL5564109 | — | Ki | = | 382.0 | nM | 6.42 |
| CHEMBL5590540 | — | Ki | = | 989.0 | nM | 6.00 |