Assay Detail
Binding
CHEMBL5536401
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SOS1/KRAS G12D mutant (unknown origin) protein-protein interaction
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Lead Identification of Novel Naphthyridine Derivatives as Potent SOS1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.68 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4535474 | BAY-293 | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4535474 | BAY-293 | IC50 | = | 21.0 | nM | 7.68 |