Assay Detail
Functional
CHEMBL5536423
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Agonist activity at rat CB1 receptor stably expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 5 mins by Lance Ultra cAMP assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chiral Me-2-arachidonoyl Glycerols: The First Potent Endocannabinoid Glyceride Templates with Stability to COX-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.85 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | — | 1 | 8.46 |
| CHEMBL5562759 | — | — | 1 | 8.15 |
| CHEMBL5574568 | — | — | 1 | 7.77 |
| CHEMBL5572923 | — | — | 1 | 7.64 |
| CHEMBL122972 | 2-ARACHIDONOYLGLYCEROL | — | 1 | 7.60 |
| CHEMBL5573266 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5562759 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5574568 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5572923 | — | EC50 | = | 23.1 | nM | 7.64 |
| CHEMBL122972 | 2-ARACHIDONOYLGLYCEROL | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5573266 | — | EC50 | = | 34.6 | nM | 7.46 |