Assay Detail
Binding
CHEMBL5536444
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Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 2,4-Dichloro-5-sulfamoylbenzoic Acid Oxime Esters: First Studies as Potential Human Carbonic Anhydrase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.60 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120886 | — | — | 1 | 9.28 |
| CHEMBL5574542 | — | — | 1 | 9.03 |
| CHEMBL5569372 | — | — | 1 | 8.43 |
| CHEMBL5570465 | — | — | 1 | 8.28 |
| CHEMBL5572726 | — | — | 1 | 8.17 |
| CHEMBL5563676 | — | — | 1 | 8.09 |
| CHEMBL5570722 | — | — | 1 | 7.67 |
| CHEMBL5566655 | — | — | 1 | 7.53 |
| CHEMBL5589893 | — | — | 1 | 7.44 |
| CHEMBL5562673 | — | — | 1 | 7.35 |
| CHEMBL5555149 | — | — | 1 | 7.16 |
| CHEMBL5573950 | — | — | 1 | 7.07 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL5594498 | — | — | 1 | 6.59 |
| CHEMBL5564949 | — | — | 1 | 6.58 |
| CHEMBL5575026 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120886 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL5574542 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL5569372 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL5570465 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL5572726 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL5563676 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL5570722 | — | Ki | = | 21.3 | nM | 7.67 |
| CHEMBL5566655 | — | Ki | = | 29.5 | nM | 7.53 |
| CHEMBL5589893 | — | Ki | = | 36.5 | nM | 7.44 |
| CHEMBL5562673 | — | Ki | = | 44.6 | nM | 7.35 |
| CHEMBL5555149 | — | Ki | = | 69.5 | nM | 7.16 |
| CHEMBL5573950 | — | Ki | = | 84.4 | nM | 7.07 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL5594498 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL5564949 | — | Ki | = | 263.0 | nM | 6.58 |
| CHEMBL5575026 | — | Ki | = | 445.0 | nM | 6.35 |