Assay Detail
Binding
CHEMBL5536537
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Inhibition of CLK4 (unknown origin) in presence of ATP
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK4 (CHEMBL4203) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.55 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5574990 | — | — | 1 | 6.91 |
| CHEMBL5565459 | — | — | 1 | 6.80 |
| CHEMBL5579785 | — | — | 1 | 5.95 |
| CHEMBL5542886 | — | — | 1 | - |
| CHEMBL5574107 | — | — | 1 | - |
| CHEMBL5569603 | — | — | 1 | - |
| CHEMBL5575113 | — | — | 1 | - |
| CHEMBL5573038 | — | — | 1 | - |
| CHEMBL5589781 | — | — | 1 | - |
| CHEMBL5571334 | — | — | 1 | - |
| CHEMBL5569176 | — | — | 1 | - |
| CHEMBL5564156 | — | — | 1 | - |
| CHEMBL5575519 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5574990 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL5565459 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5579785 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5542886 | — | IC50 | - | — | - | |
| CHEMBL5574107 | — | IC50 | - | — | - | |
| CHEMBL5569603 | — | IC50 | - | — | - | |
| CHEMBL5575113 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5573038 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5589781 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5571334 | — | IC50 | - | — | - | |
| CHEMBL5569176 | — | IC50 | - | — | - | |
| CHEMBL5564156 | — | IC50 | - | — | - | |
| CHEMBL5575519 | — | IC50 | - | — | - |