Assay Detail
Functional
CHEMBL5536561
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Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer-Glo luminescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.63 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5574990 | — | — | 1 | 5.71 |
| CHEMBL5575113 | — | — | 1 | 5.64 |
| CHEMBL5575519 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5574990 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL5575113 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL5575519 | — | IC50 | = | 2960.0 | nM | 5.53 |