Assay Detail
Functional
CHEMBL5536658
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Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 2 hrs followed by LPS stimulation for 24 hrs by Griess reagent based assay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of chalcone analogues as anti-inflammatory agents through the regulation of NF-κB and JNK activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.12 | 5.12 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190474 | — | — | 2 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190474 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL190474 | — | Activity | - | — | - |