Assay Detail
Functional
CHEMBL5537376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as reduction in viral replication
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.37 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5173559 | — | — | 1 | 6.05 |
| CHEMBL5170425 | — | — | 1 | 5.66 |
| CHEMBL1062 | HYDROXYPROGESTERONE | — | 1 | 5.56 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 5.53 |
| CHEMBL1718454 | — | — | 1 | 5.15 |
| CHEMBL164 | MYRICETIN | — | 1 | 5.10 |
| CHEMBL485818 | BAICALIN | — | 1 | 4.55 |
| CHEMBL5590116 | — | — | 1 | - |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5173559 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5170425 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1062 | HYDROXYPROGESTERONE | EC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL8260 | BAICALEIN | EC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL1718454 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL164 | MYRICETIN | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL485818 | BAICALIN | EC50 | = | 27870.0 | nM | 4.55 |
| CHEMBL5590116 | — | EC50 | = | 112000.0 | nM | - |
| CHEMBL269277 | BETULINIC ACID | EC50 | > | 10000.0 | nM | - |