Assay Detail
Binding
CHEMBL5537388
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-2 MPro transfected in Escherichia coli BL21 (DE3) measured after 1 hr by FRET analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.06 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096283 | — | — | 1 | 6.58 |
| CHEMBL5593969 | — | — | 1 | 6.16 |
| CHEMBL5568631 | — | — | 1 | 6.14 |
| CHEMBL460499 | CARMOFUR | 2.0 | 1 | 5.74 |
| CHEMBL5563508 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096283 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5593969 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5568631 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL460499 | CARMOFUR | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL5563508 | — | IC50 | = | 2000.0 | nM | 5.70 |