Assay Detail
Binding
CHEMBL5537423
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kalpha (unknown origin) by kinase profiling assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.05 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236962 | OMIPALISIB | 2.0 | 1 | 10.40 |
| CHEMBL5562761 | — | — | 1 | 10.00 |
| CHEMBL5565411 | — | — | 1 | 8.70 |
| CHEMBL1234114 | — | — | 1 | 8.15 |
| CHEMBL5571102 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236962 | OMIPALISIB | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5562761 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5565411 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1234114 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5571102 | — | IC50 | = | 10.0 | nM | 8.00 |