Assay Detail
Functional
CHEMBL5537634
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Anti-ferroptotic activity in erastin-induced ferroptosis in mouse HT-22 cells assessed as cell viability incubated for 24 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HT-22 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 3-hydroxypyridin-4(1H)-One derivatives as ferroptosis inhibitors with iron-chelating and reactive oxygen species scavenging activities and therapeutic effect in cisplatin-induced cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.81 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3633556 | — | — | 1 | 6.72 |
| CHEMBL5572801 | — | — | 1 | 4.83 |
| CHEMBL5595227 | — | — | 1 | 4.76 |
| CHEMBL5591932 | — | — | 1 | 4.74 |
| CHEMBL5568865 | — | — | 1 | 4.71 |
| CHEMBL5569744 | — | — | 1 | 4.59 |
| CHEMBL5564177 | — | — | 1 | 4.58 |
| CHEMBL5591524 | — | — | 1 | 4.54 |
| CHEMBL5564246 | — | — | 1 | 4.47 |
| CHEMBL5571263 | — | — | 1 | 4.14 |
| CHEMBL70927 | DEFERIPRONE | 4.0 | 1 | - |
| CHEMBL7976 | CHALCONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3633556 | — | EC50 | = | 191.0 | nM | 6.72 |
| CHEMBL5572801 | — | EC50 | = | 14890.0 | nM | 4.83 |
| CHEMBL5595227 | — | EC50 | = | 17410.0 | nM | 4.76 |
| CHEMBL5591932 | — | EC50 | = | 18210.0 | nM | 4.74 |
| CHEMBL5568865 | — | EC50 | = | 19630.0 | nM | 4.71 |
| CHEMBL5569744 | — | EC50 | = | 25780.0 | nM | 4.59 |
| CHEMBL5564177 | — | EC50 | = | 26250.0 | nM | 4.58 |
| CHEMBL5591524 | — | EC50 | = | 28860.0 | nM | 4.54 |
| CHEMBL5564246 | — | EC50 | = | 33520.0 | nM | 4.47 |
| CHEMBL5571263 | — | EC50 | = | 72050.0 | nM | 4.14 |
| CHEMBL70927 | DEFERIPRONE | EC50 | = | 164600.0 | nM | - |
| CHEMBL7976 | CHALCONE | EC50 | > | 500000.0 | nM | - |