Assay Detail
Functional
CHEMBL5537673
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Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS addition and measured after 24 hrs by griess reagent based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of cinnamoyl tethered indoline derivatives with anti-inflammatory and antioxidant activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.62 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 1 | 6.41 |
| CHEMBL5589744 | — | — | 1 | 6.05 |
| CHEMBL5566040 | — | — | 1 | 5.72 |
| CHEMBL5565933 | — | — | 1 | 5.68 |
| CHEMBL5575798 | — | — | 1 | 5.45 |
| CHEMBL5590520 | — | — | 1 | 5.44 |
| CHEMBL5571768 | — | — | 1 | 5.41 |
| CHEMBL5589651 | — | — | 1 | 5.39 |
| CHEMBL5584011 | — | — | 1 | 5.35 |
| CHEMBL5575843 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5589744 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5566040 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5565933 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL5575798 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL5590520 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL5571768 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5589651 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL5584011 | — | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL5575843 | — | IC50 | = | 5000.0 | nM | 5.30 |