Assay Detail
Toxicity
CHEMBL5538252
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Displacement of 1,8-ANS from N-terminal 6His-tagged full length FABP3 (unknown origin) expressed in Escherichia coli ER2566 assessed as inhibition constant preincubated with compound for 10 mins followed by 1,8-ANS addition and measured after 3 mins by fluorescence based analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.39 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5564812 | — | — | 1 | 9.43 |
| CHEMBL5571195 | — | — | 1 | 8.89 |
| CHEMBL5565638 | — | — | 1 | 8.66 |
| CHEMBL5575316 | — | — | 1 | 8.40 |
| CHEMBL5564125 | — | — | 1 | 8.29 |
| CHEMBL5563843 | — | — | 1 | 8.13 |
| CHEMBL5590346 | — | — | 1 | 8.12 |
| CHEMBL5563556 | — | — | 1 | 7.82 |
| CHEMBL5573363 | — | — | 1 | 7.81 |
| CHEMBL5575425 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5564812 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL5571195 | — | Ki | = | 1.29 | nM | 8.89 |
| CHEMBL5565638 | — | Ki | = | 2.19 | nM | 8.66 |
| CHEMBL5575316 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL5564125 | — | Ki | = | 5.18 | nM | 8.29 |
| CHEMBL5563843 | — | Ki | = | 7.46 | nM | 8.13 |
| CHEMBL5590346 | — | Ki | = | 7.51 | nM | 8.12 |
| CHEMBL5563556 | — | Ki | = | 15.03 | nM | 7.82 |
| CHEMBL5573363 | — | Ki | = | 15.37 | nM | 7.81 |
| CHEMBL5575425 | — | Ki | > | 5.0 | nM | - |