Assay Detail
Functional
CHEMBL5538347
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Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Raji |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.48 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 6.00 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.70 |
| CHEMBL5592140 | — | — | 1 | 5.34 |
| CHEMBL5569425 | — | — | 1 | 5.20 |
| CHEMBL4087968 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5592140 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5569425 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4087968 | — | IC50 | = | 6900.0 | nM | 5.16 |