Assay Detail
Binding
CHEMBL5538868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ATX in using LPC as substrate by fluorescence based microplate reader assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel UDCA-aminopyrimidine hybrids as ATX inhibitors for the treatment of hepatic and pulmonary fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.08 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5566552 | — | — | 1 | 8.12 |
| CHEMBL5575865 | — | — | 1 | 8.12 |
| CHEMBL5591143 | — | — | 1 | 7.81 |
| CHEMBL5575423 | — | — | 1 | 7.81 |
| CHEMBL5595881 | — | — | 1 | 7.56 |
| CHEMBL5562884 | — | — | 1 | 7.45 |
| CHEMBL5574060 | — | — | 1 | 7.40 |
| CHEMBL5569627 | — | — | 1 | 7.38 |
| CHEMBL5568776 | — | — | 1 | 7.36 |
| CHEMBL5567280 | — | — | 1 | 7.33 |
| CHEMBL5567151 | — | — | 1 | 7.24 |
| CHEMBL3828074 | ZIRITAXESTAT | 3.0 | 1 | 7.13 |
| CHEMBL5569443 | — | — | 1 | 7.04 |
| CHEMBL5569991 | — | — | 1 | 7.03 |
| CHEMBL5564559 | — | — | 1 | 6.99 |
| CHEMBL5572432 | — | — | 1 | 6.87 |
| CHEMBL5574522 | — | — | 1 | 6.78 |
| CHEMBL5595894 | — | — | 1 | 6.78 |
| CHEMBL5572676 | — | — | 1 | 6.78 |
| CHEMBL5594899 | — | — | 1 | 6.62 |
| CHEMBL5573906 | — | — | 1 | 6.47 |
| CHEMBL5571100 | — | — | 1 | 6.47 |
| CHEMBL5565831 | — | — | 1 | 6.36 |
| CHEMBL1551 | URSODIOL | 4.0 | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5566552 | — | IC50 | = | 7.51 | nM | 8.12 |
| CHEMBL5575865 | — | IC50 | = | 7.62 | nM | 8.12 |
| CHEMBL5591143 | — | IC50 | = | 15.39 | nM | 7.81 |
| CHEMBL5575423 | — | IC50 | = | 15.57 | nM | 7.81 |
| CHEMBL5595881 | — | IC50 | = | 27.72 | nM | 7.56 |
| CHEMBL5562884 | — | IC50 | = | 35.61 | nM | 7.45 |
| CHEMBL5574060 | — | IC50 | = | 40.19 | nM | 7.40 |
| CHEMBL5569627 | — | IC50 | = | 41.42 | nM | 7.38 |
| CHEMBL5568776 | — | IC50 | = | 43.93 | nM | 7.36 |
| CHEMBL5567280 | — | IC50 | = | 46.29 | nM | 7.33 |
| CHEMBL5567151 | — | IC50 | = | 57.83 | nM | 7.24 |
| CHEMBL3828074 | ZIRITAXESTAT | IC50 | = | 73.4 | nM | 7.13 |
| CHEMBL5569443 | — | IC50 | = | 91.72 | nM | 7.04 |
| CHEMBL5569991 | — | IC50 | = | 92.51 | nM | 7.03 |
| CHEMBL5564559 | — | IC50 | = | 102.42 | nM | 6.99 |
| CHEMBL5572432 | — | IC50 | = | 136.29 | nM | 6.87 |
| CHEMBL5574522 | — | IC50 | = | 165.11 | nM | 6.78 |
| CHEMBL5595894 | — | IC50 | = | 168.07 | nM | 6.78 |
| CHEMBL5572676 | — | IC50 | = | 164.75 | nM | 6.78 |
| CHEMBL5594899 | — | IC50 | = | 242.87 | nM | 6.62 |
| CHEMBL5573906 | — | IC50 | = | 335.34 | nM | 6.47 |
| CHEMBL5571100 | — | IC50 | = | 341.58 | nM | 6.47 |
| CHEMBL5565831 | — | IC50 | = | 438.35 | nM | 6.36 |
| CHEMBL1551 | URSODIOL | IC50 | = | 9260.0 | nM | 5.03 |