Assay Detail
Binding
CHEMBL5538898
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of extracellular arginase (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel orally bioavailable piperidine derivatives as extracellular arginase inhibitors developed by a ring expansion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.43 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5572458 | — | — | 1 | 7.70 |
| CHEMBL4218271 | NUMIDARGISTAT | 2.0 | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5572458 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4218271 | NUMIDARGISTAT | IC50 | = | 69.0 | nM | 7.16 |