Compound Detail
CHEMBL5572458
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Basic Information
| ChEMBL ID | CHEMBL5572458 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NZNAXQBYXLSQHO-JBLDHEPKSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
272.1
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Arginase-1 CHEMBL1075097 | IC50 | 7.7 | 7.7 | 20.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Arginase-1 | IC50 | = | 20.0 | nM | 7.7 | Inhibition of extracellular arginase (unknown origin) | 38096651 |
| Arginase-1 | IC50 | = | 20.0 | nM | 7.7 | Inhibition of human recombinant ARG1 expressed in Escherichia coli using L-argin... | 38096651 |
| Unchecked | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of mouse intracellular ARG in M2 polarized C57BL/6 mouse BMDM cells i... | 38096651 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38096651 | 10.1016/j.ejmech.2023.116033 | Arginase-1 | 2 |
| 38096651 | 10.1016/j.ejmech.2023.116033 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine