Assay Detail
Binding
CHEMBL5538899
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Inhibition of human recombinant ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate assessed as inhibition of urea production incubated for 20 mins by colorimetric analysis
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel orally bioavailable piperidine derivatives as extracellular arginase inhibitors developed by a ring expansion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.42 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5572458 | — | — | 1 | 7.70 |
| CHEMBL5573574 | — | — | 1 | 6.80 |
| CHEMBL5564694 | — | — | 1 | 6.68 |
| CHEMBL5590630 | — | — | 1 | 6.62 |
| CHEMBL4749434 | — | — | 1 | 6.60 |
| CHEMBL5574058 | — | — | 1 | 6.60 |
| CHEMBL5584145 | — | — | 1 | 6.60 |
| CHEMBL5569448 | — | — | 1 | 6.57 |
| CHEMBL5569123 | — | — | 1 | 6.55 |
| CHEMBL5564404 | — | — | 1 | 6.55 |
| CHEMBL5592979 | — | — | 1 | 6.55 |
| CHEMBL5573132 | — | — | 1 | 6.51 |
| CHEMBL5574720 | — | — | 1 | 6.47 |
| CHEMBL5570988 | — | — | 1 | 6.46 |
| CHEMBL5569035 | — | — | 1 | 6.44 |
| CHEMBL5572916 | — | — | 1 | 6.44 |
| CHEMBL5570457 | — | — | 1 | 6.44 |
| CHEMBL5579689 | — | — | 1 | 6.42 |
| CHEMBL5573227 | — | — | 1 | 6.40 |
| CHEMBL5570085 | — | — | 1 | 6.40 |
| CHEMBL5566718 | — | — | 1 | 6.38 |
| CHEMBL5575750 | — | — | 1 | 6.38 |
| CHEMBL5567616 | — | — | 1 | 6.21 |
| CHEMBL5569670 | — | — | 1 | 6.19 |
| CHEMBL5593553 | — | — | 1 | 6.17 |
| CHEMBL5574724 | — | — | 1 | 6.13 |
| CHEMBL5562980 | — | — | 1 | 6.12 |
| CHEMBL5563536 | — | — | 1 | 6.12 |
| CHEMBL5574905 | — | — | 1 | 6.08 |
| CHEMBL5573192 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5572458 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5573574 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5564694 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5590630 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4749434 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5574058 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5584145 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5569448 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5569123 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5564404 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5592979 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5573132 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5574720 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5570988 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5570457 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5569035 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5572916 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5579689 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5570085 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5573227 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5566718 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5575750 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5567616 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5569670 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5593553 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5574724 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5562980 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5563536 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5574905 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5573192 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5574669 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL5562639 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5573103 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5591050 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5565043 | — | IC50 | > | 10000.0 | nM | - |