Compound Detail
CHEMBL5569448
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Basic Information
| ChEMBL ID | CHEMBL5569448 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PQGFLCPJFFDDGN-DKCNOQQISA-N |
1
Targets
1
Activities
1
Assay Types
5
PK Parameters
3
Publications
0
Known Names
Molecular Properties
287.1
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Arginase-1 CHEMBL1075097 | IC50 | 6.57 | 6.57 | 270.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 5.87 | mL.min-1.kg-1 | Rattus norvegicus |
| F | 18.8 | % | Rattus norvegicus |
| F | 58.0 | % | Mus musculus |
| T1/2 | 2.66 | hr | Rattus norvegicus |
| Tmax | 1.0 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Arginase-1 | IC50 | = | 270.0 | nM | 6.57 | Inhibition of human recombinant ARG1 expressed in Escherichia coli using L-argin... | 38096651 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38096651 | 10.1016/j.ejmech.2023.116033 | ADMET | 9 |
| 38096651 | 10.1016/j.ejmech.2023.116033 | Arginase-1 | 1 |
| 38096651 | 10.1016/j.ejmech.2023.116033 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine