Assay Detail
Binding
CHEMBL5539627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus Sortase A N24 deletion mutant transpeptidation using IsdA64-323 as substrate preincubated for 20 mins followed by substrate addition and measured after 1.5 hrs by SDS-PAGE analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Guided Design, Synthesis, and Antivirulence Assessment of Covalent <i>Staphylococcus aureus</i> Sortase A Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.00 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570289 | — | — | 1 | 5.28 |
| CHEMBL5174805 | — | — | 1 | 5.13 |
| CHEMBL5569180 | — | — | 1 | 5.13 |
| CHEMBL270142 | — | — | 1 | 5.09 |
| CHEMBL5569374 | — | — | 1 | 5.09 |
| CHEMBL5574464 | — | — | 1 | 5.05 |
| CHEMBL5574890 | — | — | 1 | 5.05 |
| CHEMBL5573262 | — | — | 1 | 4.82 |
| CHEMBL5564769 | — | — | 1 | 4.79 |
| CHEMBL5565857 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570289 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5174805 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL5569180 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL270142 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5569374 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL5574464 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5574890 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5573262 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL5564769 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL5565857 | — | IC50 | = | 24600.0 | nM | 4.61 |