Assay Detail
Functional
CHEMBL5539736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.47 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297454 | ABBV-744 | 1.0 | 1 | 7.41 |
| CHEMBL5572023 | — | — | 1 | 7.21 |
| CHEMBL5566198 | — | — | 1 | 6.75 |
| CHEMBL5563490 | — | — | 1 | 6.70 |
| CHEMBL5569499 | — | — | 1 | 6.68 |
| CHEMBL5568960 | — | — | 1 | 6.55 |
| CHEMBL5568743 | — | — | 1 | 6.41 |
| CHEMBL5568810 | — | — | 1 | 6.27 |
| CHEMBL5566025 | — | — | 1 | 6.11 |
| CHEMBL5567469 | — | — | 1 | 5.85 |
| CHEMBL5562706 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297454 | ABBV-744 | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5572023 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5566198 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5563490 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5569499 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5568960 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5568743 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5568810 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5566025 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5567469 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL5562706 | — | IC50 | = | 5200.0 | nM | 5.28 |