Assay Detail
Toxicity
CHEMBL5540235
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at 5HT2B (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.71 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3950697 | — | — | 1 | 7.39 |
| CHEMBL3946659 | — | — | 1 | 7.37 |
| CHEMBL3966643 | — | — | 1 | 6.82 |
| CHEMBL3890986 | — | — | 1 | 6.80 |
| CHEMBL3966595 | — | — | 1 | 6.80 |
| CHEMBL3915489 | — | — | 1 | 6.70 |
| CHEMBL3982497 | — | — | 1 | 6.11 |
| CHEMBL5565713 | — | — | 1 | 5.70 |
| CHEMBL3965722 | — | — | 1 | - |
| CHEMBL5564760 | — | — | 1 | - |
| CHEMBL3982723 | DAROVASERTIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3950697 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3946659 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3966643 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3890986 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3966595 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3915489 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3982497 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5565713 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3965722 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL5564760 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL3982723 | DAROVASERTIB | EC50 | > | 30000.0 | nM | - |