Assay Detail
Binding
CHEMBL5540409
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Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrate
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of TP0628103: A Highly Potent and Selective MMP-7 Inhibitor with Reduced OATP-Mediated Clearance Designed by Shifting Isoelectric Points.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 9.48 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5574207 | — | — | 1 | 10.22 |
| CHEMBL5590289 | — | — | 1 | 9.92 |
| CHEMBL5575564 | — | — | 1 | 9.89 |
| CHEMBL5584155 | — | — | 1 | 9.77 |
| CHEMBL5575333 | — | — | 1 | 9.77 |
| CHEMBL5573957 | — | — | 1 | 9.77 |
| CHEMBL5590711 | — | — | 1 | 9.77 |
| CHEMBL5572317 | — | — | 1 | 9.70 |
| CHEMBL5572421 | — | — | 1 | 9.66 |
| CHEMBL5573293 | — | — | 1 | 9.60 |
| CHEMBL5569043 | — | — | 1 | 9.59 |
| CHEMBL5570298 | — | — | 1 | 9.59 |
| CHEMBL5575734 | — | — | 1 | 9.49 |
| CHEMBL5570760 | — | — | 1 | 9.30 |
| CHEMBL5567332 | — | — | 1 | 9.02 |
| CHEMBL5590933 | — | — | 1 | 8.80 |
| CHEMBL5417105 | — | — | 1 | 8.55 |
| CHEMBL5565065 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5574207 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL5590289 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL5575564 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL5584155 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL5575333 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL5573957 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL5590711 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL5572317 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5572421 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL5573293 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL5569043 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL5570298 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL5575734 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL5570760 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5567332 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL5590933 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5417105 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5565065 | — | IC50 | = | 7.3 | nM | 8.14 |