Compound Detail
CHEMBL5572421
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)(C)[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)CNC(=O)CC[C@H](NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1)C(=O)O)C(=O)Nc1ccc(C(=O)N2CCC(C(=O)N[C@H](CCCNC(=N)N)C(=O)NCCN)CC2)cc1
Basic Information
| ChEMBL ID | CHEMBL5572421 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PNGCWQINZYUBTM-BLEZFCBESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1136.7
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Matrilysin CHEMBL4073 | IC50 | 9.66 | 9.66 | 0.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Matrilysin | IC50 | = | 0.22 | nM | 9.66 | Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fl... | 38214909 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38214909 | 10.1021/acs.jmedchem.3c01967 | No relevant target | 2 |
| 38214909 | 10.1021/acs.jmedchem.3c01967 | Matrilysin | 1 |
Data from ChEMBL 36 via Core Engine