Assay Detail
Binding
CHEMBL5540956
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Inhibition of recombinant mouse sEH using PHOME as substrate preincubated for 10 mins followed by substrate addition by fluorescence based assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 9.25 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5592524 | — | — | 1 | 10.10 |
| CHEMBL5564312 | — | — | 1 | 9.96 |
| CHEMBL5571794 | — | — | 1 | 9.89 |
| CHEMBL5570637 | — | — | 1 | 9.72 |
| CHEMBL5569830 | — | — | 1 | 9.54 |
| CHEMBL5573866 | — | — | 1 | 9.52 |
| CHEMBL5571076 | — | — | 1 | 9.40 |
| CHEMBL5564705 | — | — | 1 | 9.40 |
| CHEMBL5564589 | — | — | 1 | 9.36 |
| CHEMBL5570460 | — | — | 1 | 9.35 |
| CHEMBL4869434 | — | — | 1 | 9.30 |
| CHEMBL5566384 | — | — | 1 | 9.30 |
| CHEMBL5574790 | — | — | 1 | 9.29 |
| CHEMBL5571505 | — | — | 1 | 9.23 |
| CHEMBL5567500 | — | — | 1 | 9.22 |
| CHEMBL5571752 | — | — | 1 | 9.22 |
| CHEMBL5591117 | — | — | 1 | 9.15 |
| CHEMBL5567303 | — | — | 1 | 9.14 |
| CHEMBL5574426 | — | — | 1 | 9.12 |
| CHEMBL5564613 | — | — | 1 | 9.11 |
| CHEMBL5570840 | — | — | 1 | 9.10 |
| CHEMBL5590604 | — | — | 1 | 9.00 |
| CHEMBL5571161 | — | — | 1 | 8.80 |
| CHEMBL5573004 | — | — | 1 | 8.19 |
| CHEMBL5563806 | — | — | 1 | 7.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5592524 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL5564312 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL5571794 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL5570637 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL5569830 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL5573866 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5571076 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5564705 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5564589 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL5570460 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL4869434 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5566384 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5574790 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL5571505 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL5567500 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5571752 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5591117 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5567303 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL5574426 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL5564613 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL5570840 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5590604 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5571161 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5573004 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5563806 | — | IC50 | = | 11.7 | nM | 7.93 |